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We develop micro- and nanoscale technologies, integrated with advanced optical imaging, to address challenges in biosensing, point-of-care diagnostics, mechanobiology, and the characterization and manipulation of biomolecules, cells, and soft biological materials. Our group has expertise in microfabrication, soft-lithography microfluidics, micropatterning, brightfield and fluorescence microscopy, high-resolution imaging, cell鈥搈aterial interactions, and the development of novel sensors, actuators, and biomedical devices. We design methods, assays, and platforms for sensitive detection, controlled confinement, quantitative characterization, and precise manipulation of biological systems. Current research directions include:

• Microfluidic platforms for single-cell capture and pairing, and controlled application of shear, compressive, and extensional forces
• Heart-on-a-chip systems for mechanically stimulating engineered cardiac tissues and evaluating cellular responses
• Sensor-integrated biomedical devices for continuous physiological monitoring and point-of-care diagnostics
• Hydrodynamic trapping and programmable manipulation of particles, cells, and biomolecules in microfluidic flow networks
• Microfluidic and optofluidic sensors for biomolecular detection, microbial analysis, and characterization of soft particles
• High-resolution and high-throughput imaging methods for quantifying cellular behavior, mechanotransduction, and cell鈥揷ell interactions

Overall, we pursue a multidisciplinary research program that combines engineering, biology, and physical science to create microfluidic and optofluidic tools for fundamental biological discovery, disease modeling, therapeutic screening, and biomedical diagnostics.

I embrace the 鈥渆ducate, inspire, engage鈥� approach. My overall objective in teaching and advising (mentoring) is to foster a positive learning environment in order to engage students in acquiring, testing and generating knowledge, and to attain skills indispensable for establishing themselves as distinguished individuals of the next generation of engineers. I envision my role as a teacher/mentor to motivate students by curbing their enthusiasm and stimulating their interest; and eventually empower them to think creatively and independently.

I teach the following courses under our undergraduate and graduate programs in Biomedical Engineering:

• ENGR 110 Programming for Engineers
• BMED 310 Biomedical Signals and Systems
• BMED 451W/551W Biomedical Microdevices I
• BMED 452/552 Biomedical Microdevices II

Synopsis:

2 book chapters, 22 journal articles, 11 conference proceedings, 4 issued/pending patents,

Web of Science: h-index: 14, total citations: 902, total publications: 35,

Scopus: h-index: 14, total citations: 964, total publications: 37,

Google Scholar: h-index: 16, total citations: 1421, total publications: 64,

Selected recent publications are listed below:

Book chapter:

1. Tanyeri M, and Tay S

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Methods in Cell Biology, Volume 148

Microfluidics in Cell Biology Part C: Microfluidics for Cellular and Subcellular Analysis (2018)

Editors: Daniel A. Fletcher, Junsang Doh and Matthieu Piel, ISBN: 978-0-12-814284-4, Elsevier.

Journal

1. Mansoor H, Juul G, Patel J, Pradhan H, Hepner G, Jewell J, Bardin M, Slusser R, Glezer A, Klouda L, Tanyeri M, Saraf A
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Advanced Science, 2026, DOI: 10.1002/advs.202523820

2. Tanyeri M

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Biomedical Engineering Education (2025) 5, 69鈥�77. DOI: 10.1007/s43683-024-00161-7

3. Mustafa A, Ertas Uslu M, and Tanyeri M

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Sensors (2023) 23(22), 9265. DOI: 10.3390/s23229265

4. Yang B, Schinke J, Rastegar A, Tanyeri M, and Viator JA

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Bioengineering (2023) 10(11), 1268. DOI: 10.3390/bioengineering10111268

5. Mustafa A, Haider D, Barua A, Tanyeri M, Erten A, and Yalcin O

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Sensors and Diagnostics (2023) 2, 1509-1520. DOI: 10.1039/d3sd00099k

6. Boyd J, Hepner G, Ujhazy M, Bliss S, and Tanyeri M

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Physics of Fluids (2023) 35, 062001. DOI: 10.1063/5.0150089

7. Mustafa A, Eser A, Aksu AC, Kiraz A, Tanyeri M, Erten A, and Yalcin O

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Analytica Chimica Acta (2020) 1135 107-115. DOI: 10.1016/j.aca.2020.07.039

8. Watterson WJ, Tanyeri M, Watson AR, Cham CM, Shan Y, Chang EB, Eren AM, and Tay S

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eLife (2020) 9:e56998. DOI: 10.7554/eLife.56998

9. Evans A, Sutton K, Hernandez S, and Tanyeri M

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Journal of Annals of Bioengineering (2019) 1: 61-64. DOI: 10.33513/BIOE/1901-06

Patents

1. Tanyeri M, Lin J, Abasiyanik F, Angarita Marmolejo YD

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US Application No: 63/184,447 (May 5, 2021), WO 2022/235284 (Nov 10, 2022).

2. Yalcin O, Erten AC, Tanyeri M

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US Patent 11,998,911 B2 (Jun 4, 2024), EPO Patent 3830573 (Oct 16, 2024). WO 2020/027741 (Feb 6, 2020).

Conference Proceedings

1. Hoying M, Kazimer B, Evans A, Carbino B, Sutton K, McCallin R, and McGee A

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IEEE Aerospace Conference (AERO) (2022) pp. 01-10, DOI: 10.1109/AERO53065.2022.9843386.

Selected recent presentations are listed below:

Invited:

1. 鈥淢icrofluidic techniques for probing molecular and cellular processes鈥�

91制片厂, Biological Sciences Seminar

Pittsburgh, PA (October 27, 2023)

2. 鈥淢icrofluidic tools for studying biomolecules, cells and soft matter鈥�

Ohio State University, Biophysics Seminar

Columbus, OH (September 29, 2021)

3. 鈥淗ydrodynamic Trap: A new microfluidic tool for studying soft matter鈥�

Carnegie Mellon University, Colloids, Polymers and Surfaces Seminar

Pittsburgh, PA (March 9, 2018)

4. 鈥淥bservation of droplet dissolution in aqueous media using a hydrodynamic trap鈥�

3rd World Chemistry Conference

Dallas, TX (September 11-12, 2017)

Contributed:

1. Biomedical Engineering Society (BMES 2026) Annual Meeting (oral)

鈥淧ressure-Driven Non-Planar Mechanical Loading Reveals Preload-Dependent Structural and Transcriptomic Remodeling of Human iPSC-Derived Cardiomyocytes鈥�

Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Leda Klouda, Melikhan Tanyeri, Anita Saraf

Orlando, FL (Oct 21-24, 2026)

2. Biomedical Engineering Society (BMES 2025) Annual Meeting (poster)

鈥淪equential Capture and Pairing of Cells and Particles Using a Microfluidic Array鈥�

Merve Ertas Uslu, Shainy Ojha, Sara Knox, Mark Bardin, Jayakrishnan Thamattumadom Unnikrishnan, Michael Smutny, Till Bretschneider, Melikhan Tanyeri

San Diego, CA (Oct 8-12, 2025)

3. 2025 (7^th) Carnegie Mellon Forum on Biomedical Engineering (poster)

鈥淐ell Pairing via Fibronectin Micropatterning for Studying Intercellular Mechanobiology鈥�

Jay Unnikrishnan, Melikhan Tanyeri

Carnegie Mellon University (September 19, 2025)

4. 2025 (7^th) Carnegie Mellon Forum on Biomedical Engineering (poster)

鈥淢odel-Guided Design of Microfluidic Traps for Controlled Cell Pairing鈥�

Mark Bardin, Merve Ertas Uslu, Melikhan Tanyeri

Carnegie Mellon University (September 19, 2025)

5. National Conference on Undergraduate Research (NCUR 2025) (poster)

鈥淢icrofluidic Fabrication of Monodisperse Alginate-based Hydrogel Microparticles鈥�

Sara Knox, Merve Ertas Uslu, Melikhan Tanyeri

Pittsburgh, PA (Apr 7-9, 2025)

6. National Conference on Undergraduate Research (NCUR 2025) (poster)

鈥淥ptimizing Laser-Induced Graphene Fabrication on Polyimide for Flexible and Stretchable Bioelectronic Sensors鈥�

Jackson Jewell, Chandler Last, Melikhan Tanyeri, Leda Klouda, Panayiota Senekkis-Florent

Pittsburgh, PA (Apr 7-9, 2025)

7. 51^st Northeast Bioengineering Conference (NEBEC 2025) (poster)

鈥淏ioreactor for Studying the Impact of 3D cyclic strain on iPSC-derived cardiomyocytes鈥�

Gabrielle Juul, Haris Mansoor, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Ryan Slusser, Leda Klouda, Anita Saraf, Melikhan Tanyeri

New York University, NY (April 4-5, 2025)

8. 51^st Northeast Bioengineering Conference (NEBEC 2025) (poster)

鈥淢icrofluidic Fabrication of Monodisperse Alginate-based Hydrogel Microparticles鈥�

Sara Knox, Merve Ertas Uslu, Melikhan Tanyeri

New York University, NY (April 4-5, 2025)

9. 51^st Northeast Bioengineering Conference (NEBEC 2025) (poster)

鈥淔lexible biosensors: The e铿�ect of laser engraving parameters on direct writing of electrodes onto polyimide substrates鈥�

Jackson Jewell, Chandler Last, Leda Klouda, Panayiota Senekkis-Florent, Melikhan Tanyeri

New York University, NY (April 4-5, 2025)

10. 12^th Annual BioE Day (CMU & Pitt) (poster)

鈥淔lexible biosensors: The e铿�ect of laser engraving parameters on direct writing of electrodes onto polyimide substrates鈥�

Jackson Jewell, Chandler Last, Leda Klouda, Panayiota Senekkis-Florent, Melikhan Tanyeri

University of Pittsburgh (March 20, 2025)

11. 12^th Annual BioE Day (CMU & Pitt) (poster)

鈥淢icrofluidic Fabrication of Monodisperse Alginate-based Hydrogel Microparticles鈥�

Sara Knox, Merve Ertas Uslu, Melikhan Tanyeri

University of Pittsburgh (March 20, 2025)

12. Biomedical Engineering Society (BMES) Annual Meeting (poster)

鈥淎 Microfluidic Method for Cell Trapping and Pairing towards Mechanobiology Studies鈥�

Merve Ertas Uslu, Shainy Ojha, Michael Smutny, Till Bretschneider, Melikhan Tanyeri

Baltimore, MD (Oct 23-26, 2024)

13. Chicago Bioengineering Conference (CBEC) (poster)

鈥淒igital CFU: Rapid bacterial enumeration method based on droplet microfluidics and machine learning鈥�

Shawn Bliss, Daniel Angarita, Matt Nestler, Melikhan Tanyeri

Chicago, IL (Sep 30 鈥� Oct 1, 2024)